17. ИРН AP23484165 «Clinical-diagnostic and morphologic determinants of diseases of the large intestine: innovative approaches and solutions» (Igisin Nurbek Sagynbekuly)

Information on scientific and (or) scientific-technical projects of grant financing by Ministry of Science and Higher EducationRepublic of Kazakhstan

1) Grant financing Grant financing of scientific and (or) scientific-technical projects for 2024-2026 (implementation period 36 months)

Project summary

Project title

ИРН AP23484165 «Clinical-diagnostic and morphologic determinants of diseases of the large intestine: innovative approaches and solutions»

Project manager

Igisin Nurbek Sagynbekuly, Doctor of Medical Sciences, Professor

Implementation period

2024-2026

Amount of funding

Total amount of the project 148,831,632.50 tenge (one hundred forty-eight million eight hundred thirty-one thousand six hundred thirty-two) tenge 50 tiyn, including a breakdown by year, to perform works according to item 3:

- for 2024 - in the amount of 41,998,952.50 tenge (forty-one million nine hundred ninety-eight thousand nine hundred fifty-two) tenge 50 tiyn;

- for 2025 - in the amount of 52,839,880 (fifty-two million eight hundred thirty-nine thousand eight hundred eighty) tenge 00 tiyn;

- for 2026 - in the amount of 53,992,800 (fifty-three million nine hundred ninety-two thousand eight hundred) tenge 00 tiyn.

Topicality

Colorectal diseases represent a wide range of medical conditions, including colorectal cancer, Crohn's disease, nonspecific ulcerative colitis, polyposis, and diverticulosis, which have a significant impact on human health and are priorities for modern medicine. These pathologies, among the most prevalent in the world, pose serious challenges in prevention, diagnosis and treatment, requiring a detailed study to improve the effectiveness of health care.

In our study, the main objective is to develop innovative strategies and methods for the prevention, diagnosis and treatment of colorectal diseases. Colorectal cancer, in particular, is one of the leading types of cancer, and our study aims to better understand its molecular and genetic features in order to identify novel approaches for early diagnosis and personalized treatment.

Crohn's disease and non-specific ulcerative colitis, characterized by chronic intestinal inflammation, require special attention. We plan to study not only the clinical manifestations of these diseases, but also to delve deeper into the molecular mechanisms of inflammation in order to identify new markers for diagnosis and therapy.

Polyposis and diverticulosis, although different in nature, are also important research targets. We focus on investigating the mechanisms of their formation, and developing methods of prevention and early diagnosis to improve clinical practice.

The modern approach to medicine is increasingly focused on personalizing diagnosis and treatment. Our research focuses on individual risk factors in the development of colonic diseases, such as genetic predispositions and microbiota characteristics, to develop personalized treatment and prevention strategies.

With recent discoveries in the gut microbiota, we raise an important question about the influence of the microbial community on the development and progression of colorectal diseases. Understanding this interaction may open new perspectives for therapy and prevention, including the microbiota as a target for novel therapeutic strategies.

Our research is not limited to improving standard methods of diagnosis and treatment. We aim to create innovative approaches that will improve diagnostic accuracy, treatment efficacy, and prognosis of colorectal diseases.

Studying risk factors and the effectiveness of preventive measures is a key part of our research. The intention is not only to identify risk factors but also to develop specific prevention strategies, for example through early detection and interventions in high-risk groups, including genetically determined predispositions.

Modern lifestyles, including diet and physical activity levels, have a significant impact on the health of the large intestine. We plan to conduct a comprehensive study to identify specific lifestyle aspects that contribute to or prevent the development of diseases such as diverticulosis. This will not only allow us to develop effective recommendations for prevention, but will also emphasize the importance of a healthy lifestyle in public health.

The results of our research will have practical application in medical practice. We plan to create recommendations for physicians based on our scientific findings to improve the diagnosis, therapy, and prevention of colorectal diseases. These recommendations will also be incorporated into public health programs, providing additional resources for effective management of these diseases.

Colorectal diseases are not confined to the borders of individual countries, and our research has global relevance. We seek to build international partnerships and networks to share expertise and data, facilitating better international coordination of efforts to prevent and treat these diseases. This approach helps create uniform standards of care and sharing of best practices, which is especially important in a global medical environment.

With current trends in medicine emphasizing early detection of diseases, research on the clinical and morphological determinants of colorectal diseases is in line with this trend. We believe that our scientific findings will lead to the development of innovative methods to improve the prognosis and quality of life of patients.

In summary, our research on colorectal diseases represents not only a relevant area in science and medicine, but also a strategically important contribution to improving public health. We aim to create new knowledge that will not only be used in everyday medical practice, but also contribute to the formation of new approaches to the diagnosis, treatment and prevention of colorectal diseases.

Objective

The objectives of the research project focus on a thorough analysis of diseases of the large intestine with the subsequent development of innovative approaches to their diagnosis and investigation. Our goal is to study in depth the pathologies of this organ, taking into account modern standards and recommendations, in order to develop promising methodologies for surgical research.

Project outcomes

- for 2024:

Analysis of existing early diagnosis methods: Survey of current screening methods to assess their compliance with international standards. Identify reasons for possible low levels of early diagnosis and propose improvements.

Study of tumor morphology: Conduct a detailed analysis of the morphology of colorectal cancers to identify regional features that may differ from diseases elsewhere.

- For 2025:

A methodology for the diagnosis of colorectal diseases will be developed and recommended.

One (1) article will be published based on the results of the study in a peer-reviewed foreign scientific publication indexed in the Web of Science or Scopus database.

- For the year 2026:

Development of regional clinical guidelines: Based on the findings, create regional clinical recommendations that take into account unique regional characteristics.